Eman Ahmed Abd El Aty, from Alexandria, Egypt, once weighed 1,100lbs, and before her surgery earlier this year had not left her bed since her pre-teens.
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Doctors at Burjeel Hospital in Abu Dhabi said Miss Ahmed Abd El Aty had died due to complications from her weight, including heart disease and kidney dysfunction.
The hospital said: ‘Our prayers and heartfelt condolences go out to her family.’
Doctors blamed her weight on a thyroid condition, while her family claimed she suffered from elephantitis, a parasitic infection which causes extreme swelling in a person’s limbs and arms.
Her family has said that she has been heavy all her life, even as a baby. By the time she was 11 she was too heavy to walk, and had to crawl to get around.
Not long after, she suffered a cerebral stroke, which left her bedridden, causing her to pile on the pounds.
After a desperate plea for help, a doctor in Mumbai offered to take on her case free of charge.
In March Miss Ahmed Abd El Aty was flown Mumbai on a modified plane designed to deal with her sizeable 1,100lb frame.
After first losing more than 220 pounds in order to fit onto the operating table, she successfully underwent a gastric sleeve surgery and was reported in April to have lost 660 lbs – more than half of her body weight.